基于腰痛宁指纹图谱多指标成分定量方法研究

Multicomponent quantitative method of Yaotongning Capsule based on the fingerprint

目的:探讨以腰痛宁胶囊(马钱子,土虫,全蝎,乳香,没药等)的指纹图谱指纹峰为基准峰计算多指标成分的定量方法。方法:建立腰痛宁的指纹图谱,达到基线分离的峰确定为指纹峰,以士的宁峰为基准峰,计算基准峰中士的宁的含量,其它指纹峰以士的宁为参照,计算每个指纹峰以士的宁计的含量。结果:确定了腰痛宁12个指纹峰,计算出指纹峰以士的宁计的含量。结论:建立了腰痛宁多指标成分的定量方法,方法具有可操作性,使指纹图谱在药品质量控制中更具意义。

AIM ： To investigate the quantitative method in the form of fingerprint peaks of Yaotonning （Semen Sttychni, Eupolyphage seu steleophaga, Scorpio, Olibanum, Myrrha, etc ） as benchmark peak. METHODS： The fingerprints of Yaotongning Capsule were obtained, the peaks which can separate from the baseline were defined as fingerprint peaks, and the peak of strychnine was appointed as the benchmark peak. All the fingerprint peaks were quantified grounded on the peak of strychnine. RESULTS： Twelve fingerprint peaks were defined, and quantified rested on the peak of strychnine. CONCLUSION ： A multieomponent quantitative method for Yaotongning Capsule is established. The established method is feasible.