高血压大鼠不同血管平滑肌肌球蛋白磷酸化和脱磷酸化酶的变化

CHANGES OF ACTIVITIES OF MLCK AND DEPHOSPHATASE IN DIFFERENT ARTERIAL VESSELS FROM HYPERTENSIVE RATS

本文比较了正常和高血压大鼠不同动脉血管肌球蛋白轻链激酶（MICK和依赖Ca2+的钙调素磷酸酶（Ca2+／CaM－PP）活性的变化。结果表明：在自发性高血压大鼠（SHR）不同血管MLCK的活性不同，依次为主动脉（A）＞尾动脉（CA）＞肠系膜动脉（MA）；而在WKY大鼠，该酶在不同血管的活性依次为A＜＜CA＜＜MA。在WKY大鼠，MACa+／CaM-PP活性明显高于SHR．在肾性高血压大鼠（RHR）的不同血管Ca2+／CaM－PP活性与Wistar大鼠比较，无明显差异。上述结果表明：MLCK活性升高或／和Ca2+／CaM－PP活性（或水平）降低可能与血管收缩及高血压发病有关。

The changes of activities of myosin light chain kinase(MLCK)and Ca2+/CaM-PP in different arterial vessels from hypertensive and normotensive rats were studied.The results were as follows.The MLCK activity of different arteries of spontanous hypertensive rats(SHR)was different with the order of aorta(A)＞＞caudal artery (CA)＞＞mesenteric artery (MA),while in WKY rats the order of activity among different arteries is A＜＜CA and MA and MA Ca2+/CaM-PP is obviously higher than in SHR.In renal hpertensive ras the activities of Ca2+/CaM-PP in different arteries are no quite different from those of the Wistar rats.The above results suggest that higher activities of MLCK or/and lower activity might be related to vasocontraction and hypertension.