老年早期无症状动脉粥样硬化危险因素的临床分析

Clinical Analysis of Risk Factors in Early Stage of Atherosclerosis in the Elderly

目的:分析老年早期无症状动脉粥样硬化的危险因素。方法:对204名老年人进行脉搏波传导速度的测量并以1 400 cm/s为界,将所有对象分为对照组与无症状动脉粥样硬化组,比较各危险因素在两组中的情况。结果:无症状动脉粥样硬化组的空腹血糖、超敏C-反应蛋白、尿酸、血压和体重指数水平显著高于对照组(P<0.05)。Logistic回归显示血糖、超敏C-反应蛋白和收缩压是老年人无症状动脉粥样硬化的独立危险因子。结论:血糖、超敏C-反应蛋白和收缩压在早期动脉粥样硬化的发展过程中起了促进作用,加强对这些影响因素的早期预防和干预有望减少心血管事件的发生。

To analyze the characteristics of subclinical atherosclerosis in the elderly. Methods： A total of 204 hospitalized old patients were recruited and divided into subclinical atherosclerosis group and normal control group according to pulse wave velocity （PWV）, by which, the subclinical atherosclerosis was defined as PWV≥1 400 cm/s. Each risk factor was compared between the two groups. Results： FPG, hs-CRP, uric acid, blood pressure, and BMI were significantly higher in the subclinical atherosclerosis group （all P〈0.05）. Logistic regression demonstrated that FPG, hs-CRP, and SBP were independent risk factors of subclinical atherosclerosis in the elderly. Conclusion：FPG, hs-CRP, and SBP are important risk factors in the development of subclinical atherosclerosis. Early intervention on these risk factors may reduce the chances of future cardiovascular events