α_1-肾上腺素受体的信号转导

Signal Transduction of α1Adrenoceptors

α１肾上腺素受体可激活细胞内多种信号转导途径，除经典的磷酸肌醇钙信号系统与二酰基甘油蛋白激酶Ｃ信号系统外，还包括磷脂酶Ａ２花生四烯酸信号系统，酪氨酸激酶磷酸化系统与腺苷酸环化酶ｃＡＭＰ信号系统等。α１ＡＲ所介导的诸多瀑布式的链级信号系统，呈网络状连接在一起，一种信号系统的激活可引发、加强或阻抑另一信号系统。这些信号系统参与α１ＡＲ介导的一系列生理和病理生理过程。不同的α１ＡＲ亚型所介导的信号转导途径存在差异，但有些实验中显示的差异是由于采用的组织或细胞不同所致。

α1adrenoceptors activate multiple signal transduction pathways. In addition to the classic inositol phosphatesCa^2+ system and diacylglycerolprotein kinase C system, the phospholipase A2arachidonic acid system, the tyrosine kinase phosphorylation system, the adenylate cyclasecAMP system etc. were also involved. These signal transduction cascades interact complicatedly with each other as a network. The activation of one signal system can initiate, potentiate or inhibit other systems. They play pivotal role in diversified physiological and pathophysiological processes. Different α1adrenoceptor subtypes activate different signal transduction pathways.In some experiments, however, the differences are due to the different tissues or cells used.