细胞因子在类风湿性关节炎滑膜炎和关节破坏中的作用

The function of cytokines in the pathogenesis of synovitis and articular destruction of rheumatoid arthritis

类风湿性关节炎(RA)是一种慢性炎症性疾病,其主要靶点是滑膜,关节软骨和骨。细胞因子(CK)是由免疫细胞和某些非免疫细胞产生的调节性蛋白质,作为细胞介质,调节免疫与炎症应答。CK直接而广泛地参与RA发病相关的众多免疫学进程。本文就细胞因子的关键性效应子功能在RA滑膜炎和关节破坏中的重要作用作一综述。

Rheumatoid arthritis is a chronic inflammatory disease that mainly targets the synovial membrane,cartilage and bone. Cytokines are regulatory proteins that are produced by immunocyte or some nonimmune cells and act as intercellular mediators in the generation and control of immune and inflammatory responses. Cytokines are directly implicated in many of the immune processes that are associated with the pathogenesis of rheumatoid arthritis. This review focuses on the crucial effector function of cytokines in the immunological processes that are central to the pathogenesis of synovitis and articular destruction of rheumatoid arthritis.