血浆B型脑钠肽浓度变化对急诊呼吸困难病人诊断及鉴别诊断的临床价值观察被引量：1

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摘要目的探讨血浆B型脑钠肽(BNP)水平变化在心源性,非心源性呼吸困难患者中诊断和鉴别诊断的临床意义。方法选取以呼吸困难为主诉来我院急诊就诊的患者117例,分为心源性呼吸困难组74例,非心源性呼吸困难组43例。其中心源性呼吸困难组按照超声心动图检查结果分为单纯舒张功能不全组29例,单纯收缩功能不全组26例,收缩并舒张功能不全组19例;按照纽约心功能分级标准对心功能进行分析。测定各组患者血浆BNP水平,用SPSS12.0软件对各组资料进行分析。结果心源性与非心源性呼吸困难组BNP水平有显著差异;心源性呼吸困难组中单纯收缩功能不全,单纯舒张功能不全与收缩并舒张功能不全病人BNP水平有显著差异;按照纽约心功能分级标准,不同心功能亚组之间BNP有差异;心源性呼吸困难组血浆BNP水平与LVEF之间有相关性(P<0.05)。结论血浆BNP水平变化对于急诊呼吸困难尤其是心源性和非心源性呼吸困难的诊断和鉴别诊断有重要价值。

作者徐进军贾静周正直

机构地区河北省蔚县人民医院

出处《安徽医药》 CAS 2009年第5期531-532,共2页 Anhui Medical and Pharmaceutical Journal

关键词 B型脑钠肽心力衰竭呼吸困难

分类号 R541.6 [医药卫生—心血管疾病] R472.9 [医药卫生—护理学]

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参考文献7

1Valli N,Gobinet A,Bordenave L. Review of 10 years of the clinical use of brain natriuretic peptide in cardiology [ J ]. J Lab Clin Med,1999,134:437 -44.
2Cowie MR, Mendez GF. BNP and congestive heart failure [ J ]. Prog Cardiovas Dis ,2002,44:293 - 321.
3Mc Cullough PA, Sandberg KR. Sorting out the evidence on natriuretic peptides[J]. Rev Cardiovasc Med ,2003,4(suppl4) :S13 - S19.
4Maisel AS, Krishnaswamy P,Nowak RM,et al. Rapid measurement of B - type natriurteic peptide in the emergency diagnosis of heart failure[ J]. N Engl J Med ,2002,347 : 161 - 7.
5史晓敏,林箐,徐国宾,宋以信,夏铁安.血清N末端B型钠尿肽原在心功能评价及慢性充血性心力衰竭诊断中的初步应用[J].中华检验医学杂志,2005,28(1):37-41. 被引量：76
6MeDonagh TA, Robb SD, Murdoch DR, et al. Biochemical detection of left - ventricular systolic dysfunction[ J]. Lancet ,1998,351:9 - 13.
7Richards AM, Nicholls MG, Espiner EA, et al. B-type natriuretic peptides and ejectionfraction for prognosis after myocardial infraction [ J ]. Circulation,2003,107 : 2786 - 92.

二级参考文献10

1史晓敏,宋以信,徐国宾,夏铁安.人血清N端脑钠肽水平参考值范围及其测定稳定性的初步调查[J].中国实验诊断学,2004,8(5):451-455. 被引量：18
2Hunt PJ, Richards AM, Nicholls MG, et al. Immunoreactive amino-terminal pro-brain natriuretic peptide (NT-PROBNP): a new marker of cardiac impairment. Clin Endocrinol, 1997, 47:287 -296.
3Yeo KT , Wu AH , Apple FS, et al. Multicenter evaluation of the Roche NT-proBNP assay and comparison to the Biosite Triage BNP assay. Clin Chim Acta, 2003, 338:107-115.
4Cowie MR, Struthers AD, Wood DA, et al. Value of natriuretic peptides in assessment of patients with possible new heart failure in primary care. Lancet, 1997, 350:1349-1353.
5McDonagh TA, Robb SD, Murdoch DR, et al. Biochemical detection of left-ventricular systolic dysfunction. Lancet, 1998, 351:9-13.
6Pfister R, Scholz M, Wielckens K, et al. Use of NT-proBNP in routing testing and comparison to BNP. Eur J Heart Fail, 2004, 6:289 -293.
7Seino Y, Ogawa A, Yamashita T, et al. Application of NT-proBNP and BNP measurements in cardiac care: a more discerning marker for the detection and evaluation of heart failure. Eur J Heart Fail, 2004, 6:295-300.
8McCullough PA, Sandberg KR. B-type natriuretic peptide and renal disease. Heart Fail Rev, 2003, 8:355 -358.
9Richards AM , Nicholls MG , Yandle TG , et al. Plasma N-terminal pro-brain natriureitc peptide and adrenomedullin: new neurohormonal predictors of left ventriculation function and prognosis after myocardial infarction. Circulation, 1998, 97:1921-1929.
10张国华,胡韵,史晓敏,徐国宾,夏铁安.B型钠尿肽的生物学特性及其在心脏病学中的临床应用进展[J].中华检验医学杂志,2004,27(4):262-265. 被引量：75