康复新口服液联合“三联疗法”治疗消化性溃疡80例临床研究

Clinical Research of the Effect of Kangfuxin Liquid Combined with Triple Therapy in Treating 80 Cases with Peptic Ulcer

目的观察康复新口服液联合"三联疗法"治疗幽门螺杆菌(HP)相关的消化性溃疡(PU)的临床疗效。方法将经胃镜检查确诊的160例幽门螺杆菌(HP)感染相关的消化性溃疡(Pu),随机分两组。对照组:80例,泮托拉唑40mg+阿莫西林1.0+呋喃唑酮100mg,2次/d,三联治疗7d后,继续单用泮托拉唑40mg,1次/d,连服5周;治疗组80例,是在对照组基础上加服康复新液10mL,5次/d,共4周。于治疗前后进行临床症状严重程度评分,胃镜下溃疡愈合情况,HP根除情况及治疗后半年溃疡复发情况评估。结果两组治疗对比显示,治疗后都能明显缓解临床症状,而治疗组比对照组临床症状改善更为迅速,1个月后胃镜复查,溃疡愈合率,总有效率,HP根除率,治疗组分别为87.5%、97.5%、93.8%,对照组分别为50.0%、92.5%、87.5%,治疗组痊愈率优于对照组(P<0.01),总有效率及HP根除率无明显差异(P>0.05),治疗后1年溃疡复发率,治疗组20.0%,对照组41.3%,两组有显著差异(P<0.01)。结论康复新液能迅速改善消化性溃疡的临床症状,促进溃疡愈合,缩短愈合疗程,减少和预防溃疡复发,康复新液联合泮托拉唑三联疗法治疗HP相关的消化性溃疡疗效可靠,值得推广应用。

Objective To explore the clinical curative effect of Kangfuxin Liquid combined with the triple therapy of pantoprazole, amoxyicillin and furazolidone in treating HP - associated peptic ulcer. Methods 160 cases with HP - associated peptic ulcer confirmed by gastroscopic examination were randomly divided into 2 groups ： treatment group （ n = 80 ） and control group （ n = 80 ） ;triple therapy of 40 mg of pantoprazole, 1.0 g of amoxyicillin and 100 mg of furazolidone was given to control group ,twice a day for 7 days, and only 40 mg, once a day for 5 week;for treatment group, besides the same treatment of control group, 10 ml of Kangfuxin Liquid were added ,5 times a day for 4 weeks ;the scoring of the clinical symptom severity ,the ulcer healing and HP e- radication observed under gastroscope and the recurrence half a year after treatment were made in both group before and after treatment. Results The contrast between the 2 groups showed that the clinical symptoms of both groups relieved obviously while symptom improvement in treatment group was quicker than that in control; gastroscopie reexamination was made 1 month after treatment which indicated that the ulcer healing rate, the total effective rate and HP eradication rate in treatment group were 87. 5% ,97.5% and 93.8% respectively while those in control group were 50. 0% ,92. 5% and 87.5% respectively,the cure rate of treatment group was superior to that of control group （P 〈0. 01 ） ,there was no obvious difference in total effective rate and HP eradication rate between the 2 groups （P 〈 0. 05 ） ;1 year after treatment, ulcer reoccurrence rate was 20.0% in treatment group and 41.3% in control group ,the difference between the 2 groups was obvious （P 〈 0. 01 ）. Conclusions Kangfuxin Liquid can rapidly improve the eliuical symptoms of peptic ulcer, promote the healing of ulcer, shorten the course, decrease and prevent the reoccurrence of ulcer; Kangfuxin Liquid combined with the triple therapy is reliable and effective in treating HP - associated peptic ulcer and it is worthy of wide application.