外周T细胞淋巴瘤化疗的回顾及进展

Systemic review on progress of drug therapy for peripheral T-cell lymphoma

虽然诊断学在不断进步,但外周T细胞淋巴瘤(PTCL)的临床诊治尚不令人满意,原因可能在于该类病例稀少以及其生物学的不均一性。目前PTCL临床预后和治疗尚落后于弥漫大B细胞性淋巴瘤(DLBCL)。随着研究深入,近年新的治疗手段不断出现,不少新药的作用已明确,新的药物组合治疗方案的尝试也已展开。

Peripheral T-cell lymphoma （PTCL） is an uncommon group of diseases that shows distinct racial and geographic variation. Given disease rarity and biological heterogeneity, advances in diagnosis, prognosis and treatment have lagged behind diffuse large B cell lymphoma （DLBCL）. However, numbers of new therapies have been studied for patients with PTCL. The activities of new drugs have been described in studies specifically for PTCL, and attempts at novel combinations are beginning.