C型肉毒梭菌毒素对小白鼠LD_(50)测定及现场灭鼠效果观察

The Mice LD_(50) Determination and Rodent Control Field Tests with Botulinum Type C

目的：观察Ｃ型肉毒梭菌毒素对小白鼠的ＬＤ５０及现场灭鼠效果。方法：毒力测定采用定量药液灌胃法；用粉迹法调查鼠密度，计算灭鼠率。结果：该药在２５℃、３０℃、３５℃放置４８小时，对小白鼠的ＬＤ５０分别为００８９１±００４７３、０１３６３±００５９７和０１７１２±００６５２ｍｌ／ｋｇ；现场试验，昼最高气温２０～２５℃，夜最低气温１５～１８℃，３个试点村的灭鼠率分别为９１０８％、８９４１％、８８０４％。结论：Ｃ型肉毒梭菌毒素的毒力甚强。

The paper reported the Mice LD_(50) determination and Rodent control field tests with Botulinum Type C. The LD_(50) were 0.0891±0.0473 ml/kg by 25℃ for 48h; 0.1363±0.0597 ml/kg by 30℃ for 48h;0.1712±0.0652ml/kg by 35℃ for 48h. The Botulinum Type C was powerful for rodent control. In the field tests with rice baits, the killing rate by the Botulinum Type C was 91.08%; 89.41% and 88.04%. It was showed that the Botulinum Type C fit in with the South China.