复方糖尿1号、2号胶囊临床应用110例疗效观察

Investigation for the effevt 110 cases by clinical application of compound formula diabetes capsules No 1 ＆ No 2

目的观察复方糖尿1号、2号降血糖药物的疗效与安全。复方糖尿1号、2号胶囊，是一组治疗糖尿病的专用药物（批准文号：湘药制字7220060119及Z20060110；发明专利号ZL97013536．9）。临床应用10年来，深受广大糖尿病友的喜爱。复方中除含人参、三七、山茱萸、肉桂等中药成份外，还含有少量的格列本脲与盐酸二甲双胍。那么，它与同品种、同剂量的西药相比较，是否有优胜之处？方法针对这一问题，把110例2型糖尿患者分为复方组与纯西药组进行临床观察比较；将110例2型糖尿病患者分为复方组与纯西药组，分别测量其：空腹血糖（FPG）、餐后2h血糖（PG2h）、餐后1hC肽（CP-1h）、餐后1h胰岛素（Ins-1h）、尿素氮（BUN）、谷丙转氨酶（SGPT），并记录两组患者的气虚症状（如：乏力、神疲）；消化道反应等。结果在降餐后血糖方面，复方组与对照组比较，P〈0．01，且消化道症状发生率仅为10％，气虚症状好转率为69％；且在治疗剂量下，所观察的病例未见到对肝、肾功能的不良影响及低血糖事件。结论复方组在降血糖方面，其稳定性好、离散性小，效果更佳；在改善气虚症状、减少消化道反应方面，也均优于纯西药组，是一组安全有效的降血糖药物。

Objective To investigate the effect and safety of hypoglycemic agents of the compound formula diabetes No. 1＆No. 2. The compound formula diabetes capsules No. 1＆No. 2 are a special group of medicine for treating diabetes. （ Apporval No ： Xiang yaozhizi Z 20060119＆Z 20060110, Patent No ：ZL97013536.9）. For 10 years＇ clinical application, they are popular among the numerous diabetes. The compound formula not only contains the chinese medicinal compositions, such as： ginseng, notoginseng, comus, cinnamon, also involves a few of glinben clanide and mdtformin hydro-chloride. Then, has it an advantage by comparing with the same kind and same dose of the western medicine. Methods To this problem, we took clinical investigation by divding 110 cases diabetes II into two groups（ the compound formula group and the pure western mesicene group）. Separately examed ： FPG, PG2 H, CP-1 h, 1ns-1 h, BUN, SGPT and wrote down each group＇s vacuity symptoms （ such as： lack of strength, fatigued spirit） and the reaction of oligestive system. Results In the aspect for hypoglycine after meal, the compound formula group for 63.1143 ,P 〈0. 001 by comparing with another group, and the happening rate of digestive symptoms only 10%, the vacuity symptoms getting better at 69%, under the amount of dosage, no abnormal effection on liver and kidney, and no hypoglycemia. Conclusion The compound formula group has ga good stability, a little dissipation and better result in hypoglyeine;and is also better than the pure western medieing group in improving vacuity symptom and in digestive system. The compound formula diabetes capsules No. 1 ＆No. 2 are a safe and effective group of medicine for treating diabetes.