有无妄想精神分裂症患者事件相关位P300亚成分研究

To investigate the P300 subcomponents in schizophrenia with or without the delusion

目的研究有妄想与无妄想精神分裂症患者事件相关电位P300亚成分的异同。方法采用美国Nicolet Bravo脑电生理仪，检测50例精神分裂症患者及50例正常对照的P300亚成分，并运用阳性和阴性症状量表（Positive and Negative Syndrome Scale，PANSS），对患者进行精4神症状的评定，按PANSS量表中阳性量表P1项得分≥3分者归入有妄想组，其余归入无妄想组。结果两组与正常对照比较，在四个记录区，P3a、P3b波幅下降，差异有统计学意义（P〈0．01）。两组比较，无妄想组，P3a波幅在C3、Pz区降低，差异有统计学意义（P〈0．05），P3b波幅在四个记录区，均降低，差异有统计学意义（P〈0．05）。结论精神分裂症患者存在认知功能的损害，无妄想组精神分裂症患者认知功能损害程度重。

Objective To investigate the differences of P300 subcomponents in schizophrenia with or without the delusion. Methods P300 subcomponents were recorded with a USA Nicolet Brovo instrument from 50 schizophrenic patients and 50 normal controls, clinical symptom of the patients were assessed using Positive and Negative Syndrom Scale（PANSS）. P1 score ≥3 minutes according to the PANSS positive belongs to with the delusion group, others belong to without the delusion group. Results Compared with the normal group, For P300 subcomponent amplitude significantly decreased at four electrodes （C3, CA, CZ, PZ）, the difference had remarkable or the unusual significance （P 〈 0. 01 ）. Two groups of comparisons, the P3a subcomponent amplitude at C3 and Pz area reduce for without the delusion group, the difference was significance （P 〈 0. 05 ）, the P3b subcomponent amplitudes at foure electrode reduces, grouped differences were observed （ P 〈 0.05 ）. Conclusion worsened brain cognitive function in schizophrenic patient, cognition function extent of damage to be heavy for without the delusion group schizophrenic patient.