摘要
目的探讨染色体核型分析在骨髓增生异常综合征(MDS)诊断、预后评估中的价值。方法采用骨髓短期培养法和R显带技术对58例MDS患者进行染色体核型分析,同时追踪其临床病情进展情况。结果58例MDS患者中有31例(53.4%)检出异常克隆。在异常染色体核型中+8和高度复杂异常最多。58例患者经追踪观察,19例(30.5%)患者转化为急性白血病。结论染色体核型分析在MDS诊断预后评估方面具有重要价值。
Objective To explore theralue of karyotype analysis in MDS for diagnosis, cure and prognosis. Methods Chromosome analysis was performed in 58 cases of MDS using the short-term culture of bone marrow cell and R-banding technique, meanwhile, their clinical progress was followed up. Results Karyotype analysis showed that 31 cases(53.4% ) had clonal Karyotypic abnormalities. The nost common chromosomal aberrations included +8 and high complex karyotypic, and then-7/Tq-In the following up, 19 cases (30. 5% ) transformed into acute leukemia. Conclusion The Karyotype analysis is very important for diagnosis, cure and prognosis of MDS.
出处
《中国临床实用医学》
2009年第3期56-57,共2页
China Clinical Practical Medicine