tryptase和chymase表达与食管癌临床病理因素的相关性

Relationship between Expression of tryptase and chymase and Clinicopathological characteristics in Esophageal Carcinoma

目的探讨食管癌组织中肥大细胞(mast cell,MC)的标记物类胰蛋白酶(tryptase)和类糜蛋白酶(chymase)表达与食管癌临床病理特征的关系。方法采用免疫组织化学染色方法对71例食管癌根治术手术标本中MC进行检测,探讨tryptase和chymase的表达与食管癌的组织学分级、浸润深度及淋巴结转移之间的关系。结果食管癌组织内的MC主要分布于癌旁交界区。tryptase的表达与食管癌的组织学分级和浸润深度呈显著的负相关性,chymase的表达与食管癌各临床病理参数均无关。结论tryptase阳性的MC与食管癌的生物学行为有相关性,对食管癌患者预后评估有一定的参考价值。

Objective To investigate the relationship between the expression of tryptase and chymase and clinical pathological features of esophageal carcinoma. Methods Tumorous tissues from 71 patients with esophageal carcinoma were collected and stained with immunohistochemical technique. The gender, histological grades, depth of invasion, lymph node metastasis rate, tryptase and chymase of these patients were analyzed. Results Mast cells resided predominantly in the marginal area of the tumor. The expression of tryptase, but not chymase was negatively correlated to the differential degree and the depth of tumor invasion of the esophageal carcinoma. Conclusion There are correlations between the positive expression of tryptase in mast cells and esophageal cancinoma biological behaviour. Mast cell with the positive expression of tryptase infiltrating the matrix of the tumor may play an important role in preventing the invasion of esophageal cancinoma and mast cells may be of value to predict the prognosis of esophageal cancinoma.