生物型腰椎间融合器的研制及生物力学研究

A novel biometerial fusion cage for lumbar interbody fusion and its biomechanics

目的:研究和开发一种新型的腰椎间融合器——生物型腰椎间融合器,并对该融合器进行生物力学测验。方法:融合器设计为用整块的异体皮质骨制成以保证其强度,融合器有特定形状和规格;从两具强壮壮年男性的新鲜尸体上截取四段股骨中上段,按设计制成融合器并冻干,然后利用瑞典进口的材料生物力学实验机,进行力学测验,测定融合器的压缩破坏力,并将结果与文献报道进行比较分析。结果:该组融合器的压缩破坏力为(10 040±1 805)N,和碳素纤维融合器比较差异无显著性(P﹥0.05),与髂骨块比较差异有显著性(P<0.05)。结论:生物型腰椎间融合器强度可以满足作为融合器的即刻支撑重建脊柱初期的稳定性的作用。

Objective To develop a novel lumbar intervertebaral body fusion cage, a biometerial cage, and examine its biomechanies. Methods The fusion cage was made of an entire piece of fresh allograft cortical bone and cooled to try, having its specific shape and size. The magnitude of the load that the cage had to carry was measured by a Sweden biomechanieal testing machine, and the findings were compared with those from other medical literatures. Results The maximum load level of this biometerial cage was （10 040±1 805 ）N, significantly different from that of the cage using slices of autograft ilium （P 〈 0.05 ）, but not different from that of the carbon-fiber cage （P 〉 0.05）. Conclusion The load that this biometerial cage can carry satisfies the need to support the initial stability of the reconstructed spinal column.