开颅术后患者呼吸机相关肺炎的危险因素

The risk factors for ventilator-associated pneumonia in patients undergoing craniotomy

目的:研究开颅术后患者患呼吸机相关肺炎(VAP)的危险因素。方法:收集我院重症监护治疗病房(ICU)开颅术后的149例患者作为研究对象,将18个可能的危险因素先进行单因素分析,在此基础上进行多因素Logisitic回归分析。结果:149例颅脑术后机械通气患者共有94例发生VAP。多因素Logisitic回归分析表明先前使用抗生素、机械通气时间≥6 d、应用制酸剂≥5 d、住ICU时间≥7 d是VAP发生的独立危险因素。结论:VAP的发生是多因素综合导致的,必须采取综合性的预防措施才能有效控制。

Objective To explore the risk factors for ventilator-associated pneumonia （VAP） in patients undergoing craniotomy. Methods The data of one hundred forty-nine patients on mechanical ventilation after craniotomy were collected. 18 possible risk factors for VAP were examined by univariate analysis and then by multivariate logistic regression analysis. Results Of 149 patients, 94 developed VAP. Multivariate logistic regression analysis indicated that prior antibiotic use, duration of mechanical ventilation ≥ 6 days, antacid use for ≥5 days, and length of ICU stay ≥7 days were the independent risk factors for VAP. Conclusions VAP is induced by multiple factors. A comprehensive measure should be taken to control the occurrence of VAP.