布地奈德联合班布特罗治疗小儿咳嗽变异型哮喘的疗效研究

Combination therapy with budesonide and bambuterol in children with cough-variant asthma

目的:探讨布地奈德联合班布特罗治疗小儿咳嗽变异型哮喘的临床疗效。方法:2005年6月至2007年6月78例咳嗽变异型哮喘患儿,随机分为两组,观察组39例,采用布地奈德联合班布特罗治疗;对照组39例,单独采用布地奈德治疗,对比观察两组的临床疗效。结果:观察组的临床控制率及总有效率均明显高于对照组,差异有统计学意义(P<0.05)。治疗1、2周时观察组FEV1、FEV1%都较治疗前明显升高,差异有统计学意义(P<0.05),而且观察组FEV1、FEV1%都较对照组升高明显,差异有统计学意义(P<0.05)。结论:布地奈德联合班布特罗治疗小儿咳嗽变异型哮喘,疗效显著,肺功能状态改善明显,不良反应少,是治疗咳嗽变异型哮喘的有效方法。

Objective To explore the efficacy of combination therapy with budesonide and bambuterol in children with cough-variant asthma. Methods From June 2005 to June 2007, 78 pediatric patients were randomly assigned to receive budesonide plus bambuterol （study group, 39 patients） or budesonide alone （control group, 39 patients）. The efficacy was compared in the two groups. Results The rates of clinical control and total effectiveness were significantly higher in the study group than in the control group （P 〈 0.05）. As compared with the baseline, both FEV1 and FEV1% were markedly elevated in the study group one to two weeks after treatment （P 〈 0.05）. The improvement in FEV1 and FEV1% was evidently greater in the study group than in control group （P 〈 0.05）. Conclusions Dual therapy with budesonide and bambuterol is effective in children with cough-variant asthma and can improve the pulmonary function, with less adverse events.