止淋Ⅰ号胶囊抗炎及利尿作用的实验研究

Experimental Study of Zhilin Ⅰ Hao Capsule on Anti-inflammatory and Diuresis Effect

目的:观察止淋Ⅰ号胶囊抗炎及利尿的疗效,并对其进行实验药理学研究。方法:将72只小鼠随机分为6组,每组12只,依次为阴性对照组、阳性药对照阿司匹林组、肾炎四味片组和止淋Ⅰ号胶囊低、中、高(1.0、2.0、3.3mg/g)组,小鼠致炎后比较各组鼠耳肿胀程度。Wistar大鼠按体质量分为5组,每组10只,依次为阴性对照组、阳性药对照肾炎四味片组、氢氯噻嗪组和止淋Ⅰ号胶囊低、高剂量组,阴性对照组灌以1%生理盐水50μL/g,实验组大鼠则灌以含有上述剂量被试药物的等量盐水,测定各组尿量及排钠、钾的量。结果:低、中剂量抗炎作用与肾炎四味片组相似(P>0.05),较阿司匹林组弱(P<0.05);高剂量组抗炎作用较肾炎四味片组强(P<0.01),与阿司匹林组相似(P>0.05),低、高剂量组给药后尿量较阴性对照组明显增加(P<0.05),同时可促进尿钠排泄,但对尿钾排泄无影响。结论:止淋Ⅰ号胶囊具有一定的利尿和抗炎作用。

Objective： To investigate the effect of Zhilin Ⅰ hao capsule on anti-inflammatory and diuresis in rats, Study on pharmacological actions. Methods： Seventy-twomice were randomly divided into 6 groups including negative control group （Tylose）, positive control group, aspirin group, Shenyan Siweipian group and Zhilin Ⅰ hao capsule groups （1.0, 2.0, 3.3 mg/g ）. The differences of auricle swelling were detected and compared in all of groups. Fifty Wistar rats were randomly divided into 5 groups including negative control group （1% saline, 50μL/g）, positive control group, Shenyan Siweipian group ,Hydrochlorothiazide group and Zhilin Ⅰ hao capsule groups （1.0, 3.3 mg/g ）,to detect urine output and the content of Sodium（Na^＋） and potassium（K＋） in urine. Results： There were no significant differences in anti-inflammatory effects between Zhilin I hao capsule group （1.0, 2.0 mg/g ） and Shenyan Siweipian group （P〉 0.05）. There was a inferior anti-inflammatory effect in Zhilin I hao Capsule groups （1.0, 2.0 mg/g ） compared to that of aspirin group （P 〈 0.05 ）; There was a higher antiinflammatory effect in Zhilin I hao Capsule groups（3.3 mg/g ） compared to that of Shenyan Siweipian group （P 〈 0.01 ）and no difference compared to that of aspirin group （P 〉 0.05 ）. The more significant diuresis was found in Zhilin I hao capsule group （3.3 mg/g ） than that of negative control group （P 〈 0.05）. Conclusion： The study suggested the anti-inflammatory and diuresis effect of Zhilin Ⅰ hao capsule in rats.