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N-甲基-D-天冬氨酸受体与中枢神经系统缺血性疾病的关系 被引量：3

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摘要 N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate)是兴奋性氨基酸谷氨酸(Glu)的特异性受体,属配体电压双重门控的离子通道,由3种不同的亚基组成的功能复合体,目前已发现N-甲基-D-天冬氨酸受体(NMDAR)至少存在7个亚单位,参与学习、记忆形成及神经系统的发育等生理功能,病理情况下,NMDAR还与中枢神经系统缺血性神经毒性损害密切相关,本篇将对NMDAR的结构、功能及其参与中枢神经系统神经毒性损害的机制作一综述。
作者 宋启民 杨卫忠 陈春美
机构地区 福建医科大学附属协和医院神经外科福建省协和医院神经外科研究所
出处 《国际神经病学神经外科学杂志》 2009年第2期185-188,共4页 Journal of International Neurology and Neurosurgery
基金 福建省卫生厅青年科研课题资助项目(编号2008-1-26)
关键词 NMDAR 生理功能 神经毒性 拮抗剂
分类号 R741 [医药卫生—神经病学与精神病学]
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参考文献25

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同被引文献39

  • 1刘江萍,龙全铭.脑白质疏松与血管性痴呆的相关因素分析[J].贵州医药,2004,28(7):596-599. 被引量：24
  • 2曲静,张洪涛,杨惠林.兔腰动脉阻断建立脊髓缺血再灌注动物模型的实验研究[J].中国临床康复,2004,8(20):4006-4007. 被引量：6
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  • 8Tuezu k,Koja y,Kunyoshi k,et al.Blood distribution to the anterior spinal artery from each segment of intercostal and lumbar arteries[J].Cardiovasc Surg,2003,44(5):637-645.
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国际神经病学神经外科学杂志
2009年 第2期

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