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活性维生素D缺乏导致牙齿和下颌骨的发育障碍 被引量：1

Active vitamin D deficiency resulted in defects of tooth and mandible development
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摘要 目的:为了检测活性维生素D缺乏及其母乳成分的改变是否影响小鼠下颌骨以及牙齿的发育。方法:通过采用X线摄影、微CT和组织学等方法比较分析25羟维生素D3的1α羟化酶杂合子[1α(OH)ase+/-]和纯合子[1α(OH)ase-/-]母鼠所喂养的纯合子和杂合子小鼠下颌骨以及牙齿的表型差异。结果:母乳中的钙水平在1α(OH)ase-/-母鼠较1α(OH)ase+/-母鼠为低。1α(OH)ase-/-仔鼠的牙量和骨量较同窝1α(OH)ase+/-仔鼠明显下降,而由1α(OH)ase-/-母鼠所喂养仔鼠的牙量和下颌骨骨量比由1α(OH)ase+/-母鼠喂养的仔鼠要低。由1α(OH)ase+/-母鼠所喂养的1α(OH)ase+/-仔鼠牙量和下颌骨量最高,而由1α(OH)ase-/-母鼠所喂养的1α(OH)ase-/-仔鼠牙量和下颌骨量最低。结论:活性维生素D和高乳钙摄入各自具有刺激下颌骨和牙齿矿化和发育的作用,又具有协同作用。 Objective：To determine whether effects of active vitamin D deficiency and subsequent alterations of milk contents on tooth and mandible development in sucking pups. Methods：Comparison of tooth and mandible phenotypes between 25-Dihydroxyvitamin D3 1α-hydroxylase heterozygous[ 1α（OH）ase^＋/-] and homozygous[ 1α（OH）ase^-/-] sucking mice at 2-week-old fed by 1α（OH）ase^＋/- or 1α（OH）ase^-/- dames by radiography, micro-CT and histology. Results：Milk calcium levels were decreased in 1α（OH）ase^-/- dames compared with that in 1α（OH）ase^＋/- dames. Dental volume and bone volume in mandibles were reduced in 1α（OH）ase^-/- pups compared with those in their 1α （OH）ase^＋/- littermates. Dental volume and bone volume in mandibles were also reduced in pups fed by 1α （OH）ase^-/dames compared with pups fed by 1α（OH）ase^＋/- dames. Dental volume and bone volume in mandibles were the highest in 1α（OH）ase^＋/- pups fed by 1α（OH）ase^＋/- dames and were lowest in 1α（OH）ase^-/- pups fed by 1α（OH）ase^-/- dames. Conclusion： Active vitamin D and high milk calcium intake stimulate the mineralization and development of teeth and mandibles respectively and have cooperative action.
作者 王骞 苗登顺
机构地区 南京医科大学口腔医学院
出处 《南京医科大学学报（自然科学版）》 CAS CSCD 北大核心 2009年第5期618-622,共5页 Journal of Nanjing Medical University(Natural Sciences)
基金 江苏省卫生厅基金资助(H200627)
关键词 1 25(OH)2D3 1-α羟化酶 下颌骨 牙齿发育 1,25 （OH） 2D3 1 α-hydroxylase mandible dental development
分类号 R591.44 [医药卫生—内科学]
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南京医科大学学报（自然科学版）
2009年 第5期

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