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表观遗传学在白血病研究中的新进展 被引量：3

Novel progress of epigenetic modification in leukaemia
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摘要 近年来研究表明表观遗传学异常是白血病发病机制中的重要组成部分。许多白血病都伴随表观遗传学的异常变化。白血病的DNA去甲基化治疗和组蛋白去乙酰化抑制剂治疗是建立在表观修饰的基础上不同于传统化疗的新方法，目前已开始应用于几种白血病的治疗。现就DNA甲基化和组蛋白修饰在白血病的发生、发展、治疗和预后等方面的最新进展作简要介绍。 Recent studies indicated that epigenetic abnormality is the important molecular mechanism in leukemia. The change of epigenetic modification occurs in most kinds of leukaemia. Based on the epigenetic modification, the therapies of leukemia with hypomethylating agents and histone deacetylases inhibitors, which are different from traditional chemotherapy are applied in the treatment of leukemia at beginning. The aim of this article is to summarize the recent advances of DNA methylation and histone modification in leukaemia occurrence, treatment and prognosis.
作者 程焕臣(综述) 邱林(审校) 马军(审校)
机构地区 哈尔滨血液病肿瘤研究所
出处 《白血病．淋巴瘤》 CAS 2009年第5期309-312,共4页 Journal of Leukemia & Lymphoma
关键词 白血病 甲基化 乙酰化作用 遗传学 Leukemia Methylation Acetylation Genetics
分类号 R392.2 [医药卫生—免疫学] R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献23

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二级参考文献27

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共引文献37

同被引文献34

  • 1王楠,阎征,刘娜.组蛋白去乙酰酶抑制剂的药理学研究进展[J].中国新药杂志,2004,13(7):594-598. 被引量：2
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  • 3林晓燕,孙玲,邹宏志,乐晓萍,郭学军,刘延芳,孙慧,邹典斌.急性淋巴细胞白血病中hMSH2mRNA及突变型P53蛋白的表达[J].中国实验血液学杂志,2005,13(6):948-950. 被引量：1
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引证文献3

二级引证文献4

白血病．淋巴瘤
2009年 第5期

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