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丙戊酸钠对帕金森病小鼠多巴胺能神经元及胶质细胞源性神经营养因子表达的影响 被引量：3

Effects of valproate on dopaminergic neurons and expressions of GDNF in Parkinson's disease mice
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作者 张玉梅 吴雪飞 于德钦 彭岩 封艳辉 张万琴 赵杰
机构地区 大连医科大学生理学教研室
出处 《中国药理学通报》 CAS CSCD 北大核心 2009年第5期695-696,共2页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30400143) 教育部博士点基金资助项目(No20040161004)
关键词 丙戊酸钠 帕金森病 多巴胺 胶质细胞源性神经营养因子 VPA Parkinson＇s disease dopamine GDNF
分类号 R-332 [医药卫生] R322.86 [医药卫生—人体解剖和组织胚胎学]
  • 相关文献

参考文献7

  • 1赵欣,蒲小平,耿兴超.松果菊苷对帕金森病模型小鼠黑质纹状体蛋白表达影响的双向电泳分析[J].中国药理学通报,2008,24(1):28-32. 被引量：27
  • 2Greenblatt D Y,Cayo M A,Adler J T.Valproic acid activates Notch1 signaling and induces apoptosis in medullary thyroid canceRcells[J].Ann Surg,2008,247(6):1036-40.
  • 3Lin L F,Doherty D H,Ltle J D,et al.GDNF:a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons[J].Science,1993,260(5111):1130.
  • 4Maruyama J,Miller J M,Ulfendahl M.Glial cell line-derived neurotrophic factor and antioxidants preserve the electrical responsiveness of the spiral ganglion neurons after experimentally induced deafness[J].Neurobiol Dis,2008,29(1):14-21.
  • 5Sonntag K C,Simantov R,Isacson O.Stem cells may reshape the prospect of Parkinson′s disease therapy[J].Mol Brain Res,2005,134(1):34-51.
  • 6S1evin J T,Gash D M,Smith C D,et al.Unilateral intraputaminal glial cell line derived neurotrophic factor in patients with Parkinson disease:response to 1 year each of treatment and withdrawal[J].Neurosurg Focus,2007,106(4):614-20.
  • 7Onofrj M,Thomas A,Paci C.Reversible parkinsonism induced by prolonged treatment with valproate[J].J Neurol,1998,245(12):794-6.

二级参考文献15

共引文献26

同被引文献27

  • 1梁建辉,韩容.行为敏化动物模型在药物依赖性评价中的应用[J].中国药理学通报,2004,20(7):726-730. 被引量：29
  • 2Schfer M,Goodenough S,Moosmann B,et al.Inhibition ofglycogen synthase kinase 3βis involved in the resistance tooxidative stress in neuronal HT22cells[J].Brain Research,2004,1005(1-2):84-89.
  • 3Koh SH,Song C,Noh MY,et al.Inhibition of glycogensynthase kinase-3reduces l-DOPA-induced neurotoxicity [J].Toxicology,2008,247(2-3):112-118.
  • 4Sarkar S,Floto RA,Berger Z,et al.Lithium inducesautophagy by inhibiting inositol monophosphatase[J].J CellBiol,2005,170 (7):1101-1111.
  • 5Struewing IT,Barnett CD,Tang T,et al.Lithium increasesPGC-1alpha expression and mitochondrial biogenesis inprimary bovine aortic endothelial cells[J].FEBS J,2007,274(11):2749-2765.
  • 6Youdim MBH,Arraf Z.Prevention of MPTP(N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)dopaminergic neurotox-icity in mice by chronic lithium:involvements of Bcl-2and Bax[J].Neuropharmacology,2004,46(8):1130-1140.
  • 7Pizzasegola C,Caron I,Daleno C,et al.Treatment withlithium carbonate does not improve disease progression in twodifferent strains of SOD1mutant mice[J].Amyotroph LateralScler,2009,10(4):221-228.
  • 8Peng GS,Li G,Tzeng NS,et al.Valproate pretreatmentprotects dopaminergic neurons from LPS-induced neuroto-xicity in rat primary midbrain cultures:role of microglia[J].Brain Res Mol Brain Res,2005,134(1):162-169.
  • 9Chen PS,Peng GS,Li G,et al.Valproate protects dopaminergicneurons in midbrain neuron/glia cultures by stimulating therelease of neurotrophic factors from astrocytes[J].MolPsychiatry,2006,11(12):1116-1125.
  • 10Kidd SK,Schneider JS.Protection of dopaminergic cellsfrom MPP+-mediated toxicity by histone deacetylaseinhibition [J].Brain Res,2010,1354(1):172-178.

引证文献3

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中国药理学通报
2009年 第5期

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