缅甸拉咱市氯喹治疗间日疟的敏感性评价

Sensitivity of Plasmodium vivax to Chloroquine in Laza City,Myanmar

缅甸拉咱市单纯间日疟原虫感染者48例分为氯喹A方案组(26例)和B方案组(22例),分别采用成人总剂量1200mg(第1天顿服600mg,第2、3天300mg/d)和1500mg(第1天顿服750mg,第2、3天375mg/d)的三天疗法治疗。于服药当天、服药后第1、2、3、7、14、21和28天采集指血或耳垂血制作厚、薄血涂片检查疟原虫,测量体温和观察药物不良反应。氯喹治疗后,两组病例血内无性体原虫3d内全部阴转。第28天随访治愈率为100%。结果表明,缅甸拉咱市的间日疟病例对氯喹治疗均敏感,该边境地区间日疟病例可采用氯喹进行临床治疗。

Fourty-eight patients infected by Plasmodium vivax were randomly divided into chloroquine regimen groups A and B. Each case in group A received a total dosage of 1 200 mg（base） over a 3-day period （600 mg on the first day then 300 mg daily）. Cases in group B each received total dosage of 1 500 mg （base） in 3 days （750 mg on the first day then 375 mg daily）. Body temperature and blood smears were examined on days 0, 1, 2, 3, 7, 14, 21 and 28, respectively. All patients were negative for asexual parasites within 3 days. The cure rate on day 28 was 100%. Results showed that P. vivax is sensitive to chloroquine in Laza, Myanmar, and chloroquine can still be used for the imported vivax malaria cases at the China-Myanmar border.