骨关节炎患者血清及滑液层粘连蛋白变化及其临床意义

THE CHANGES AND CLINICAL SIGNIFICANCE OF LAMININ LEVELS IN SERA AND SYNOVIAL FLUIDS FROM PATIENTS WITH OSTEOARTHRITIS

目的：检测骨关节炎（ＯＡ）患者血清及滑液中层粘连蛋白（ＬＮ）变化并探讨与病情的相关性。方法：应用放射免疫法测定１４例ＯＡ患者的血清及滑液ＬＮ水平，并以５份正常滑液及８份正常血清作对照，同时对ＯＡ患者血清和滑液的ＬＮ与患者的年龄、病程、血清Ｃ反应蛋白及关节Ｘ线片分级等临床资料进行相关性分析。结果：伴关节腔积液的ＯＡ患者滑液ＬＮ水平比正常组的滑液ＬＮ水平明显增高，全身型ＯＡ及Ｘ线片Ⅱ期者的血清和滑液ＬＮ水平均比膝型ＯＡ及Ⅰ期者明显增高。结论：提示滑液ＬＮ变化代表了软骨基质的病变，有其预后意义，并与关节受累多少及关节病变程度有一定相关性。

Objective:To assess the changes of laminin concentratinons in sera and synovial fluid from patients with osteoarthritis(OA).Methods:Radioimmunologic assay has been used to measure the laminin levels and relationships between levels and clinical manifestations were analyzed.Results:The results showed that the concentrations of laminin in synovial fluids from patients with OA were significantly higher than those in normal synovial fluids, meanwhile no changes were found in sera from OA compared with sera from donors.Higher laminin levels were found in synovial fluids but not in sera of patients with OA featured by grade 2 X ray in knee joints than grade 1.Conclusion:These results suggest that the laminin levels increased in synovial fluids may be a character of OA and prospect the severity of involved joints.