牛皮癣Ⅱ号汤剂治疗血热型寻常性银屑病的疗效及对外周血Th_1/Th_2漂移的影响

Effects of NiuPiXuan II Doction on the Excursion of Th_1/Th_2 in Patients with Blood-hot type Psoriasis Vulgaris

目的:观察牛皮癣Ⅱ号汤剂治疗血热型寻常性银屑病的临床疗效,并进一步探讨其对银屑病Th1/Th2漂移的影响。方法:选择78例血热型寻常性银屑病患者,随机分为牛皮癣II号治疗组(38例)和消银颗粒对照组(40例),疗程2个月。ELISA法检测血清IL-2、INF-γ、IL-4、IL-10水平,比较分析两组患者治疗前后PASI评分及血清IL-2、INF-γ、IL-4、IL-10水平,并以64例正常人作为对照。结果:治疗前,两组患者血清IL-2及INF-γ水平明显高于正常对照组;IL-4及IL-10水平明显低于正常对照组(P<0.05)。治疗后,两组患者PASI评分均明显下降,治疗组PASI评分明显低于对照组(P<0.05)。两组患者IL-2及INF-γ水平均有明显下降(P<0.05),以治疗组下降更为明显(P<0.05)。两组患者IL-4及IL-10水平均有明显升高(P<0.05),以治疗组升高更为明显(P<0.05)。结论:银屑病患者存在Thl/Th2漂移失衡,牛皮癣Ⅱ号汤剂可在一定程度上纠正Th1/Th2漂移失衡而治疗银屑病。

Objective： To investigate the clinical effects of NiuPiXuan Ⅱ doetion on treating blood -hot type psoriasis vulgaris and explore its influence on the excursion of The/The. Methods： 78 cases of blood - hot type psoriasis vulgaris were randomly divided into two groups. The treatment group （38cases） was treated with NiuPiXuan Ⅱ doction, and the contrast group（40 cases） was treated with XianYin granule. Serum levels of IL -2, INF -γ, IL -4 and IL - 10 were detected by ELISA before and after treatment, and 64 normal controls were tested also, acting as normal group. The thera- peutic effect was evaluated by PASI level. Results ： Serum levels of IL - 2 and INF -γ from patients were higher than those of normal controls and levels of IL -4 and IL - 10 from patients were lower than normal controls before treatment（ P 〈 0.05）. After 8 weeks treatment, PASI, IL - 2 and INF - ~/ levels of both patient groups declined obviously, and there was also significant difference between the treatment group and contrast group（ P 〈 0.05 ）. Levels of IL- 4 and IL -10 of both patient groups increased significanlty, and the difference between the two groups was of statistical value（ P 〈 0.05 ）. Conclusion： There was excursion of Th1/Th2 in patients with Blood - hot type psoriasis vulgaris and NiuPiXuan Ⅱ Doction can treat Blood - hot type psoriasis vulgaris througyh adjusting the disequilibrium of Th1/Th2.