环氧化酶-2及其选择性抑制剂塞来昔布与舌鳞状细胞癌侵袭的研究进展

Research progress of cyclo-oxygenase-2 selective inhibitor Celecoxib and the invasiveness of tongue squamous carcinoma

环氧化酶(COX)是致炎物质地诺前列酮合成过程中的重要限速酶。COX-2是环氧化酶的诱导型,参与炎症反应和肿瘤的发生。包括舌鳞状细胞癌在内的大多数恶性肿瘤均有COX-2的阳性表达。COX-2的活性增强还能提高细胞与细胞外基质蛋白的黏附能力,增强基质金属蛋白酶的表达水平,增加肿瘤细胞的侵袭力。进一步研究COX-2选择性抑制剂塞来昔布与舌鳞状细胞癌侵袭之间的关系,对舌鳞状细胞癌的治疗和预后有非常重要的意义。

Cyclo-oxygenase （COX） is the major rate-limiting enzyme for the synthesis of prostaglandins. COX-2, which is the inducible form, involved in inflammation and cancer incidence. Study found, COX-2 was overexpressed in the majority of malignant carcinomas including tongue squamous carcinoma. In addition, the increasing activity of COX-2 can improve the adhesion capacity of cells and the extracellular matrix protein, enhance expression level of matrix metalloprotease, and increase the invasion of tumor cells. Further studing the relationship between the cyclo-oxygenase-2 selective inhibitor and tongue squamous carcinoma invasion is very important for tongue cancer treatment and prognosis.