核转录因子-κB受体活化因子及其配体和骨保护蛋白系统在骨构建与骨改建中的作用

Regulation of receptor activator of nuclear factor-κB ligand-receptor activator of nuclear factor-κB and osteoprotegerin in bone modeling and remodeling

核转录因子-κB受体活化因子配体(RANKL)-核转录因子-κB受体活化因子(RANK)-骨保护蛋白(OPG)系统是近年发现的调节骨吸收的关键信号通路。RANKL与RANK结合在正常骨构建与骨改建中调节破骨细胞生成、活化和存留,在多种病理状况下增加骨吸收。OPG与RANK竞争性地结合RANKL,以防止骨组织的过度吸收。笔者分别就RANKL、RANK和OPG及其在骨构建与骨改建中的作用作一综述。

Receptor activator of nuclear factor-κB ligand（RANKL）-receptor activator of nuclear factor-κB （RANK） and osteoprotegerin （OPG） discovered in the mid 1990s is the key signaling system for the regulation of bone resorption. RANKL-RANK signaling regulates osteoclast formation, activation and survival in normal bone modeling and remodeling and increases bone resorption in a variety of pathologic conditions. OPG protects bone from excessive resorption by binding to RANKL and preventing it from binding to RANK. This article reviewed regulation of RANKL-RANK-OPG in bone modeling and remodeling.