妊娠期高血压疾病患者血浆脑利钠肽和尿微量白蛋白的相关性分析

Relevance of Pregnancy-induced Hypertension in Patients with Plasma Brain Natriuretic Peptide and Urinary Albumin

目的通过观察妊娠期高血压疾病患者的血浆脑利钠肽(BNP)和尿微量白蛋白、血压水平的相关性,探讨其在妊娠期高血压疾病发病中的作用及机制。方法测定80例妊娠期高血压疾病患者和40例健康产妇的血浆BNP、尿白蛋白排泄率(UAER)和血压等指标。结果妊娠期高血压疾病患者的血浆BNP、UAER、收缩压和舒张压水平显著高于健康产妇(P<0.05),血浆BNP与UAER(r=0.522)和收缩压(r=0.387)呈显著正相关。结论妊娠期高血压疾病的发生发展是多因素综合作用的结果,BNP可作为该类患者早期肾损害的预测指标。

Objective To observe the relevance of pregnancy-induced hypertension in patients with plasma brain natriuretic peptide （BNP） and urinary albumin, blood pressure level, exploring the incidence of pregnancy-induced hypertension in the role and mechanism. Methods 80 cases of pregnancy-induced hypertension patients and 40 healthy parturiens were measured for plasma BNP, urinary albumin excretion rate （UAER） and blood pressure and so on. Results The outcome of pregnancy-induced hypertension in patients with plasma BNP, UAER, systolic and diastolic blood pressure was significantly higher than that of maternal health （P 〈0.05）, plasma BNP and UAER （r = 0.522） and systolic blood pressure （r = 0.387） were significantly correlated. Conclusion The occurrence of pregnancy-induced hypertension is the development of multi-factors, BNP can be used in patients as early predictor of renal damage.