新生儿缺氧缺血性脑病高压氧治疗前后血清细胞因子水平研究

The research on treating hypoxic ischemic encephalopathy by hyperbaric oxygen treatment and the changes of cytokines

目的探讨高压氧治疗对新生儿缺氧缺血性脑病(HIE)患儿血清白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α与胰岛素样生长因子(IGF)-1水平的影响及临床意义。方法将48例中、重度HIE患儿随机分为2组,常规治疗组给予常规支持及对症治疗,高压氧治疗组在此基础上加用高压氧治疗。采用放射免疫法测定48例HIE患儿血清IL-6、TNF-α与IGF-1治疗前后变化。结果经治疗后,2组患儿IL-6水平均有上升、TNF-α与IGF-1水平均有下降。高压氧治疗组血清IL-6水平升高幅度、TNF-α与IGF-1水平降低幅度明显大于常规治疗组(P均<0.05)。结论高压氧治疗能明显降低缺血缺氧性脑病患儿IL-6、TNF-α含量,从而起到极为有益的调节作用。

Objective To investigate the changes of serum interleukin-6 （IL-6）, tumor necrosis factor-α （TNF- α） and insulin-like growth factor-1 （IGF-1） in hypoxic ischemie eneephalopathy（HIE） by hyperbaric oxygen treatment （HBOT） and clinical significance. Methods Fourty-eight neonates with HIE were divided into two groups. Routine treatment group were intervened with the conventional treatment, hyperbaric oxygenation group in addition to the conventional treatment. Serum IL-6, TNF-α and IGF-1 in 48 cases of HIE were detected by radio-immunity. Result The increaseed range of serum IL-6 in HBOT group were significantly higher than routine therapy group （P〈0.05）; the deereased range of serum TNF-α and IGF-1 in HBOT group were significantly higher than routine therapy group （P〈0.05）. Conclusion HBOT could increase the production of IL-6 and reduce the production of TNF-α and IGF-1 . HBOT is an effective therapy for hypoxic and ischemic brain damage.