子宫内膜浆乳癌及其癌前病变

Uterine papillary serous carcinoma & A putative precursor lesion of it-Endometrial glandular dysplasia

目的研究子宫内膜浆乳癌(uterine papillary serous carcinoma,UPSC)及其癌前病变-子宫内膜腺体异型增生(endometrial glandular dysplasia,EmGD)的临床病理特征及其诊治、预后。方法对该院1993～2007年住院治疗的UPSC与EmGD病人11例进行回顾性分析。结果主要临床表现为绝经后阴道流血,早期病人即可发生宫外病变,各期病人预后均差。结论输卵管绝育术不能阻止宫外病变的发生,对早期病人应做分期手术并辅助放化疗,而晚期病人的治疗应强调个体化综合治疗。

[Objective] To investigate clinical and pathological characters for uterine papillary serous carcinoma （UPSC） and the precursor lesion of it-Endometrial glandular dysplasia （EmGD）, as well to analyze the diagnosis, treatment and prognosis of them. [Method] A review of 11 cases with UPSC and EmGD from 1993 to 2007 was analyzed retrospectively. [Results] The common symptom is a postmenopausal bleeding. The patients have a tendency to manifest with extrauterine disease in early stage. The prognosis is poor in any stage. [Conclusion] The fallotoimy does not prevent the occurrence of extrauterine disease. The complete surgical staging adjuvant sequential chemotherapy and radiotherapy were necessary to the patients in early stage, while the compositive adjuvant therapy according to the patients＇ body situation is emphasized in advanced stage.