邻苯二甲酸二(2-乙基己基)酯环境暴露与人群健康研究进展

Research Advance in Environmental Exposure and Health Impact of Di(2-ethylhexyl) phthalate

邻苯二甲酸二(2-乙基己基)酯(DEHP)作为一种主要的聚氯乙烯增塑剂,广泛用在各种消费品,地板和墙壁材料,食品包装和医疗材料中。已经在水、土壤和大气中均已检出DEHP,且在人类尿样中普遍检测到DEHP的代谢产物,其在环境中已经是无处不在了,而人们可以通过水和食物等途径暴露。DEHP目前已经被列入了我国水中优先控制污染物黑名单中。大量研究表明,DEHP是一种公认的动物内分泌干扰物,具有致癌、致畸和致突变性。本文在对DEHP研究回顾的基础上,主要论述了DEHP的环境水平、代谢和生物标记以及人群健康研究的结果及进展。

As a primarily used plasticizer in polyvinyl chloride, di（2-ethylhexyl ）phthalate （DEHP） is extensively used in consumer products, flooring and wall coverings, food eontaet applications, and medical devices. Because DEHP has been detected in waters, soils and air, and its metabolites have also been detected in human urinary, sufficient evidences show that DEHP is ubiquitous in the environment worldwide. DEHP is already in the blacklist of priority pollutants in water in China. Many researches indicate that DEHP is one kind of endocrine disrupting chemicals in animals, with eareinogenieity, teratogenieity and mutagenieity. Based on the researches and review on DEHP, this paper principally discussed the environmental level, metabolism and biological markers of DEHP, as well as the research progress on human health effects.