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转录因子Pax6在胰岛发育和糖代谢调节中的作用

Role of transcription factor Pax6 in the development of pancreatic islets and the regulation of glucose metabolism
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摘要 配对盒因子6（Pax6）是一种重要的转录因子，在哺乳动物眼睛、中枢神经系统、胰岛等的发育中具有重要作用。业已证实，Pax6基因杂合子突变与糖代谢异常相关联。本文对Pax6基因在胰岛发育过程和血糖稳态调节中的作用进行讨论。 Paired box 6 （Pax6） ,a critical transcription factor,plays an important role in the devel- opment of eye, central nerve system and endocrine pancreas in mammals. It has been demonstrated that heter-ozygous mutation in Pax6 gene is associated with abnormal glucose metabolism. The role of Pax6 gene in the development of pancreatic islets as well as in the maintenance of glucose homeostasis is discussed in this article.
作者 陈园园 洪天配
机构地区 北京大学第三医院内分泌科
出处 《国际内分泌代谢杂志》 2009年第3期157-160,共4页 International Journal of Endocrinology and Metabolism
基金 国家自然科学基金资助项目（30771032,30700879） 北京市自然科学基金资助项目（7062067） 国家973计划资助项目（2006CB503900） 国家863计划资助项目（2006AA02A112）.
关键词 转录因子 PAX6 糖代谢 胰岛 发育 Transcription factor Pax6 Glucose metabolism Islet Development
分类号 R587.1 [医药卫生—内分泌]
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参考文献21

  • 1Mark M, Rijli FM, Chambon P. Homeobox genes in embryogenesis and pathogenesis. Pediatr Res, 1997,42:421-429.
  • 2Ton C, Hirvonen H, Miwa H, et al. Positional cloning and characterization of a paxbox-and hemeobox-containing gene from the aniridia region. Cell, 1991,67 : 1059-1074.
  • 3Glaser T, Walton DS, Maas RL. Genomic structure, evolutionary conservation and aniridia mutations in the human Pax6 gene. Nat Genet, 1992,2:232-239.
  • 4Wen JH,Chen YY,Song SJ,et al. Paired box 6 (Pax6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 ( PC1/3 ). Diabetologia,2009 ,52 :504-513.
  • 5Ding J, Gao Y, Zhao J, et al. Pax6 haploinsufficiency causes abnormal metabolic homeostasis by down-regulating GLP-1 in mice. Endocrinology,2009, [ Epub ahead of print].
  • 6Jun S, Desplan C. Cooperative interactions between paired domain and homeodomain. Development, 1996,122:2639-2650.
  • 7Mishra R, Gorlov IP, Chao LY, et al. Pax6, paired domain influences sequence recognition by the homeodomain. J Biol Chem, 2002,277:49488-49494.
  • 8Hanson IM, Fletcher JM, Jordan T,et al. Mutations at the Pax6 locus are found in heterogeneous anterior segment malformations including Peters' anomaly. Nat Genet, 1994,6 : 168-173.
  • 9Kozmik Z. The role of pax genes in eye evolution. Brain Res Bull, 2008,75:335-339.
  • 10Sisodiya SM, Free SL, Williamson KA, et al. Pax6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans. Nat Genet,2001,28 :214-216.

二级参考文献18

  • 1Malandrini A, Marl F, Palmeri S, et al. PAX6 mutation in a family with aniridia, congenital ptosis, and mental retardation [J]. Clin Genet, 2001,60:151 - 154.
  • 2Ton CC,Hirvonen H,Miwa H,et a1.Positional cloning and characterization of a paired box—and homeobox-containing gene from the aniridia region[J].Cell.1991,67:1059—1074.
  • 3Engelkamp D, Rashbass P, Seawright A, et al. Role of Pax6 in development of the cerebellar system [J]. Development, 1999, 126 :3585 - 3596.
  • 4Quiring R, WaUdorf U, Kloter U, et al. Homology of the eyeless gene of Drosophila to the Small eye gene in mice and Aniridia in humans[J]. Science, 1994,265:785 -789.
  • 5Schmahl W, Knoedlseder M, Favor J, et al. Defect of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey). in the mouse, a point mutation at the Pax-6 locus[J]. Aeta Neuropathol, 1993,86 : 126-135.
  • 6Stoykova A, Fritsch R, Walther C, et al. Forebrain patterning defects in Small eye mutant mice[ J ]. Development, 1996, 122:3453- 3465.
  • 7Dellovade TL, Pfaff DW, Schwanzel-Fukuda M. Olfactory bulb development is altered in small-eye (Sey) mice [ J ]. J Comp Neurol,1998. 402:402-418.
  • 8Mastick GS, Davis NM, Andrews GL, et al. Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain [J]. Development, 1997. 124 : 1985 - 1997.
  • 9Hanson IM, Fletcher JM, Jordan T, et al. Mutations at the PAX6 locus are found in heterogeneous anterior segment malformations inclucling Peters' anomaly[J]. Nat Genet. 1994.6:168 - 173.
  • 10Sisodiya SM, Free SL, Williarnson KA, et al. PAX6 haploinsufficiency causes cerebral malformation and olfactory dysfunction in humans[J]. Nature Genet. 2001. 28: 214 -216.

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国际内分泌代谢杂志
2009年 第3期

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