β受体阻滞剂对老年高血压患者生活质量影响的临床研究

β receptor blockers on the quality of life of hypertension in ageing patients

目的探讨β受体阻滞剂对老年高血压患者生活质量(quality of life,QOL)的影响。方法1,2级老年高血压患者450例,随机分为β受体阻滞治疗组(A)和非β受体阻滞治疗组(B),运用SF-36QOL量表,分别对两组观察前后的QOL进行评定。结果A组2级高血压患者治疗后比治疗前,在生理功能、生理职能、躯体疼痛和活力等方面有不同程度的改善(P<0.05);总体健康、情感职能、精神健康和社会功能方面改善不大(P>0.05);1级高血压患者的QOL,仅在总体健康改善具有意义(P<0.05),其余指标无统计学差异。B组临床观察前后QOL的各项指标比较无统计学意义(P>0.05)。结论β受体阻滞不仅能有效地抗高血压,而且能提高患者的QOL。

Objective Evaluate β receptor blockers （BB） on the quality of life （QOL） of hypertension in ageing patients. Methods 450 with 1,2 class hypertension patients randomly divided into BB treated group （A） and no BB treated group（ B）, assessed the QOL pro-or post-treatment with SF-36, respectively. Results Compared with pro-treatment in group A, physical functioning, role-physical, bodily pain and vitality of 2 class patients were improved significantly （ P 〈 0. 05 ）, while general health, role-emotional, mental health and social functioning with no statically significance（ P 〉 0.05 ） ; only general health of 1 class hypertension patients im- proved in group A （ P 〈 0. 05 ）, the rest items with no significance. In group B, all the items of QOL remained unchanged pro-or post-observations. Conclusion BB both effectively anti-hypertension and improve the QOL of hypertension patients.