肺动脉高压治疗进展

Progress in Current Treatment of pulmonary arterial hypertension

肺动脉高压(Pulmonary Arterial Hypertension,PAH)是以肺小动脉的血管痉挛、内膜增生及重构和微血栓病灶形成为主要特征的一种疾病[1]。患者最终往往死于右心衰竭。PAH是一种进展性疾病,预后较差,目前缺乏有效的治疗方案。近年来,一些新的药物和治疗方法开始应用于临床,使患者的生活质量和临床预后不断改善,现将最近的治疗进展综述如下。

Pulmonary arterial hypertension（PAH） is a disease with the main characteristics as pulmonary artery vasospasm, intimal hyperplasia and remodeling lesions and micro-thrombosis formation. Patients often died of right heart failure eventually. PAH is a progressive disease and poor prognosis. There is no effective treatment at present. In recent years, some new drugs and treatment methods were applied in clinical, making patient＇ s quality of life and clinical prognosis continue to be improved. The recent progresses of treatment are summarized as follows.