生长抑素治疗肝硬化门脉高压合并食管下段胃底静脉曲张破裂出血疗效观察

Effect of somatostatin on rupture of varices at the lower part of oesophagus and the fundus of stomach caused by portal hypertension due to cirrhosis

目的:观察生长抑素治疗肝硬化门脉高压合并食管下段胃底静脉曲张破裂出血疗效及其不良反应。方法:将40例肝硬化门脉高压合并食管下段胃底静脉曲张破裂出血患者随机分为两组,对照组22例,生长抑素治疗组18例,对照组在基础治疗(制酸、护肝、降低门脉压、补液等)上加垂体后叶素治疗;治疗组在基础治疗上加生长抑素治疗。同时观察两组止血情况及不良反应。结果:治疗组有效率88.9%,对照组有效率68.2%,两组比较差异有统计学意义(P<0.05),且治疗组不良反应少,患者耐受性好。结论:生长抑素治疗肝硬化门脉高压合并食管下段胃底静脉曲张首次破裂出血近期疗效好,不良反应少,值得临床推广使用。

Objective：To explore the effect and side-effect of somatostatin on portal hypertension caused by hepatocirrhosis, and on the rupture of veins induced by varicosity at the lower sect of oesophagus and the fundus of stomach. Methods： Forty cases of hepatocirrhosis who had portal hypertension combined with rupture of veins due to varicosity at the lower sect of oesophagus and the fundus of stomach were randomly divided into two groups：control group （22 cases）and treatment group （ 18 cases）. The control group and the treatment group were administered posterior pituitrin or somatostatin in addition to the routine therapy （such as acid-ridding, liverprotecting,pressure-lowering of portal vein and fluid-supplying）. The hemostasis and side-effects were observed in the two groups. Results：The response rates of the treatment group and the control group were 68.2% , and 88.9% , respectively. The difference was significant（P 〈0.05） ;Moreover,the treatment group demonstrated less side-effect and better toleration. Conclusions： h is concluded that somatostatin has a good curative effect on first vein rupture caused by portal hypertension due to hepatocirrhosis and varicosity at the lower sect of oesophagus and the fundus of stomach. It is worth popularizing.