血清同型半胱氨酸和高敏C反应蛋白浓度与脑梗死面积关系

Correlation of the concentration of serum homocysteine and high-sensitivity C-reactive protein with the area of cerebral infarction

目的：探讨脑梗死患者急性期血清同型半胱氨酸（Hcy）和高敏C反应蛋白（hs-CRP）含量的变化及其与脑梗死面积的关系。方法：测定59例脑梗死急性期患者和43名健康体检者血清Hcy和hs-CRP的含量，并分析两者与脑梗死面积的关系。结果：除腔隙性脑梗死患者（P〉0．05）外，大、小面积急性脑梗死患者血清Hcy和hs-CRP的浓度均高于正常对照组（P〈0．05～P〈0．01），并且随着脑梗死面积的增大，血清Hcy和hs-CRP含量亦明显增高（P〈0．01）。结论：血清Hcy和hs-CRP与脑梗死面积呈正相关。

Objective： To investigate the relationship between the changes of serum homocysteine （Hcy） and high-sensitivity C- reactive protein （hs-CRP） levels with the area of cerebral infarction in patients with acute cerebral infarction. Methods： The levels of serum Hcy and hs-CRP in 59 patients with acute cerebral infarction and 43 normal controls were measured. The relations between Hcy and hs-CRP, and the area of cerebral infarction were analyzed. Results：Except for the patients with lacunar infarction （P 〉 0.05 ） ,the levels of serum Hey and hs-CRP in all the patients with large or small area of acute cerebral infarction were higher than those in the controls （P 〈 0.05 -P 〈 0.01 ）. The levels of serum Hey and hs-CRP increased with the accretion of the infarction area （P 〈0.01 ）. Conclusions：Serum Hcy and hs-CRP levels are positively correlated to the area of acute cerebral infarction.