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“一锅法”合成2-[(2,4-二叔丁基苯氧基)甲基]-6,7-二氧戊环并[1,3-g]喹啉-3-羧酸(英文) 被引量：4

One-pot Synthesis of 2-(2,4-di-tert-Butylphenoxy) methyl-6,7-dioxolo[1,3-g]quinoline-3-carboxylic acid
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摘要 采用一锅法的合成方式有效地合成了2-(2,4-二叔丁基苯氧基)甲基-6,7-二氧戊环并[1,3-g]喹啉-3-羧酸,其特点是将威廉姆逊反应和碱水解这两步反应在"一锅里"进行。所得化合物的结构经IR、1H NMR、MS和元素分析得以证实。 Quinoline ring is a back-bone of many natural products and pharmacologically significant compounds displaying a broad range of biological activity1. For example, the anticancer alkaloid camptothecin was used as medicine against gastric cancer, tumors of the neck and carcinoma of the urinary bladder. E3.41 Many functionalized quinolines are widely used as antimalarial, anti-inflammatory agents, antibacterial,antihypertensive and tyrokinase PDGF-RTK inhibiting agents.
作者 张红 李阳
机构地区 渤海大学化学化工学院 渤海大学超精细化学品研究所
出处 《化学研究与应用》 CAS CSCD 北大核心 2009年第5期738-740,共3页 Chemical Research and Application
关键词 叔丁基 喹啉 威廉姆逊反应 碱水解 一锅法 tert-butyl quinoline Williamson reaction alkaline hydrolysis one-pot
分类号 O625 [理学—有机化学]
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参考文献10

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二级参考文献10

共引文献17

同被引文献45

  • 1李阳,崔岩,王祥,高文涛.一步法合成喹啉酸苯基醚(硫醚)类化合物[J].渤海大学学报（自然科学版）,2007,28(3):226-229. 被引量：3
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化学研究与应用
2009年 第5期

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