地诺前列酮栓用于足月妊娠促宫颈成熟引产效果

Effect of dinoprostone for cervical ripening and artificial labor in term pregnancy

目的探讨地诺前列酮栓用于足月妊娠促宫颈成熟及引产的效果与安全性。方法184例孕39-41周无严重合并症初产妇随机分为2组,每组92例。观察组孕妇阴道后穹隆放置地诺前列酮栓1枚,对照组孕妇给予1U催产素加50 g.L^-1葡萄糖500 mL,比较2组产妇的B ishop评分、产后出血、临产情况、用药至临产发作时间、阴道分娩产率、剖宫产率及新生儿窒息率。结果观察组总有效率和24 h内阴道分娩率均明显高于对照组,差异有统计学意义（P〈0.01）;观察组用药至临产时间明显短于对照组,差异有统计学意义（P〈0.05）;观察组剖宫产率明显低于对照组（P〈0.05）;2组新生儿窒息率和产后出血率比较差异无统计学意义（P〉0.05）。结论地诺前列酮栓用于足月妊娠促宫颈成熟引产安全有效。

Objective To explore the clinical effects and safety of dinoprostone for cervical ripening and artificial labor in term pregnancy. Methods 184 primipara at 39 to 41 weeks of gestation without any severity complication were randomly divided into observation group and control group,92 cases in each group. One piece of Propess was put into the vaginal posterior fornix of gravida in observe group, and Oxytocin 1U added in 50 g·L^-1 glucose of 500 mL was used intravascularly in control group. The maternal cervical Bishop score, postpartum hemorrhage, condition of labor starting, the time from given medicine to labor starting, vaginal delivery rate, cesarean section rate and neonatal asphyxia rate were compared between two groups. Results The total effective rate and vaginal delivery rate in 24 hours of observe group were higher than those of control group（ P 〈 0.01 ） ;The time from given medicine to labor starting of observe group was shorter than that of control group （ P 〈 0.01 ）. The cesarean section rate of observe group was lower than that of control group （P 〈 0. 05）. There were no significant difference in postpartum hemorrhage and neonatal asphyxia rate between two groups （P 〉 0.05 ）. Conclusion Dinoprostone was effective and safe for cervical ripening and artificial labor in term pregnancy.