蛹虫草治疗腺嘌呤致大鼠慢性肾功能衰竭的研究

Effect of Cordyceps minlitaris on Adenine-induced Rat Chronic Renal Failure

目的讨论蛹虫草及其提取物对大鼠慢性肾衰竭的作用。方法采用饲喂腺嘌呤诱导大鼠慢性肾衰(CRF)模型,观察比较了空白组、阴性对照组、阳性对照组和蛹虫草子实体组CRF模型大鼠血尿素氮、肌酐、24 h尿量、尿蛋白量,以及肾组织病理变化。结果蛹虫草子实体,尤其是其多糖组分能显著降低CRF大鼠血尿素氮、肌酐,明显减轻肾脏的病理损害。结论蛹虫草子实体及其多糖组分对延缓大鼠CRF有显著作用。

Objective To discuss the effect of Cordyceps minlitaris and its extract on rat CRF. Methods The rat chronic renal failure （CRF） model induced by feeding adenine was used to investigate rat blood urea nitrogen, creatinine, amount of emiction within 24 h, urinary protein and pathological reaction of nephridial tissue by means of comparing the blank control, negative control, positive control with the Cordyceps minlitaris stroma of CRF rats. Results The experimental results demonstrated that the Cordyceps minlitaris stroma could not only obviously reduce blood urea nitrogen and creatinine but also alleviate the pathological lesion, especially its polysaccharide. Conclusion The Cordyceps minlitaris stroma and its polysaccharide have prominent effects on the process of rat CRF.