大黄对肠缺血致肝细胞损伤防治作用的研究

EXPERIMENTAL STUDIES ON EFFECT OF RHUBARB ON HEPATOCYTE INJURY AFTER INTESTINAL ISCHEMIA REPERFUSION

目的：评价大黄对大鼠肠缺血所致肝细胞损伤的防治作用。方法：实验动物分为三组：假手术对照组，肠缺血再灌流组和肠缺血再灌流＋大黄组。分别观察肝组织脂质过氧化物（LPO）、谷胱甘肽过氧化物酶（GSH－Px），肝线粒体呼吸功能以及肝脏形态学变化。结果：应用大黄能显著降低肝组织LPO，升高GSH－Px，降低肝线粒体内膜通透性以及减轻肝脏形态学变化。结论：大黄对肠缺血所致肝细胞损伤具有防治作用。

Aim: To evaluate the effect of rhubarb on hepatocyte injury after intestinal ischemia reperfusion in rats. Methods: All rats were divided into 3 groups: sham operation, intestinal ischemia reperfusion untreated and intestinal ischemia reperfusion rhubarb treated. Liver LPO,GSH-Px and respiratory functions of liver mitochondria were measured. In addition,morphological changes in liver were observed by light microscopy. Results: Treatment with rhubarb could significantly decrease liver LPO, elevate liver GSH-Px, reduce permeability damages in the inner membrane of liver mitochondria,as well as alleviate morphologic changes in liver. Conclusion:Rhubarb may have protective effect on hepatocyte injury after intestinal ischemia reperfusion in rats.