肺表面活性物质治疗肺灌洗兔急性呼吸窘迫综合征

PULMONARY SURFACTANT THERAPY IN EXPERIMENTAL ACUTE RESPIRATORY DISTRESS SYNDROME INDUCED BY REPEATED LUNG LAVAGE

目的：用肺表面活性物质（PS）治疗肺灌洗兔急性呼吸窘迫综合征（ARDS）。方法：PS经气管插管注入肺内，分100mg·kg－1、150mg·kg－1和200mg·kg－1三个单次剂最组及100mg·kg－1×2、150mg·kg－1×2二个多次剂量组。结果：给PS后15分钟各治疗组PaO2显著增高，随后PaCO2下降、pH上升，肺顺应性改善，肺病理变化明显减轻。高剂量组疗效较低剂量组好，多次给药组较单次给药组好。结论：PS对肺灌洗兔ARDS有显著疗效。

Aim: Adult rabbits with ARDS were treated by porcine surfactant (PS). Methods: PS was instilled intratracheally in different doses (100mg·kg-1, 150mg·kg-1 and 200mg·kg-1) and different frequencies (100mg·kg-1×2, 150mg·kg-1×2). Control group was given saline only. Results: PaO2 increased 15 min after PS, then PaCO2 decreased, pH increased. Lung dynamic compliance and pathologic changes improved in treated groups. High doses was better than lower doses,frequent doses were better than single dose. Conclusion: PS was effective to animal model of ARDS.