高蛋白高脂肪饮食对普罗帕酮在大鼠体内药物动力学的影响

The effect of high protein and high fat diet on the pharmacokinetics of propafenone in rats

目的:研究高蛋白、高脂肪、高碳水化合物饮食大鼠的普罗帕酮(PPF)药物动力学,以了解饮食因素对PPF氧化代谢的影响.方法:采用HPLC法测定用药后不同时间血浆PPF浓度,用3P87程序处理数据,求得药物动力学参数.结果:与对照组相比,高蛋白饮食使PPFT(1/2β)缩短,高蛋白和高脂肪饮食均使之AUC降低,CLs增高.结论:高蛋白和高脂肪饮食加速大鼠PPF的消除.

AIM: To study the effect of high protein,high fat,and high carbohydrate diet on propafenone metabolism in rats and determine and whether dietary factors affect propafenone oxidative metabolism. METHODS: High performance liquid chromatography (HPLC) was used for the determination of concentration of propafenone. Statistical software's 3P87 was used for the calculation of results. RESULTS:In the high-protein-fed rats, the half-life of elimination (T1/2β) of propafenone was shorter, after a single dose of propafenone (100mg/kg,ig),but the area under the plasma concentration-time curve(AUC) was lower and the systemic clearance (CLs)was higher in rats both fed a high protein and high fat diet than those in rats fed a control diet. CONCLUSION: The high protein and high fat diet accelerate the elimination of propafenone in rats.