新型季鏻盐抗菌剂的合成及其抗菌性能研究

SYNTHESIS AND BACTERICIDAL ACTIVITY OF NOVEL QUATERNARY PHOSPHONIUM SALTS

采用氯甲基苯乙烯为载体,通过分子亲核取代反应,制备非溶出型高分子聚三苯基季鏻盐及小分子三苯基季鏻盐杀菌剂,并采用红外光谱图进行了结构分析;系统地研究了合成产物聚三苯基季鏻盐等的热稳定性及对SRB、TGB抗菌作用规律.结果表明,聚三苯基季鏻盐对SRB、TGB具有很好的抗菌作用.小分子三苯基季鏻盐对SRB的抗菌性能高于聚三苯基季鏻盐.

A polymeric triphenyl phosphonium salt and the corresponding low-molecular-weight triphenyl phosphonium salt were synthesized by SN2 reaction. Then their molecule structures were illustrated by IR spectrum, and the thermal stability of plolymeric triphenyl phosphonium salts was investigated by TG/DTG curves. Their antibacterial activities against sulfate reducing bacteria （SRB）and total general bacteria （TGB） were examined by maximum probable number method. The results indicated that there was good antibacterial activity of the polymeric triphenyl phosphonium against SRB and TGB, however, antibacterial activity of low-molecular-weight triphenyl phosphonium was found to be higher than that of polymeric triphenyl phosphonium against SRB.