复方血竭与柳氮磺吡啶灌肠治疗溃疡性结肠炎的疗效观察

Efficacy of Compound Dracorhodin vs.Sulfasalazine Coloclysis for Ulcerative Colitis

目的:比较复方血竭与柳氮磺吡啶(SASP)用灌肠方法治疗活动期溃疡性结肠炎的疗效和不良反应。方法:采用随机、双盲方法观察85例活动期溃疡性结肠炎的疗效和不良反应,疗程为20天。结果:治疗20天后复方血竭治疗组48例临床评价有效率为68.8%,内镜评价有效率为70.8%,组织学评价有效率为77.1%;SASP对照组37例临床评价有效率为45.9%,内镜评价有效率为48.6%,组织学评价有效率为54.1%。两组在临床、内镜及组织学评价上均有统计学差别(P<0.05)。结论:用复方血竭和SASP灌肠方法治疗活动期溃疡性结肠炎均有良好疗效,无明显不良反应,且复方血竭优于SASP。

OBJECTIVE： To evaluate the curative efficacy and side effects of Compound - dracorhodin vs. Sulfasalazine （SASP） colodysis for active ulcerative colitis. METHODS： By randomized double blind method, the curative efficacy and side effects of Compound - dracorhodin vs. Suffasalazine （SASP） coloclysis for active ulcerative colitis in 85 cases were observed, with a course of treatment of 20 days. RESULTS： After 20 - day treatment, significant differences were noted between the two groups in clinical, endoscopic and histological responsive rates （68.8 %, 70.8 % and 77.1%, respectively in Compound - dracorhodin treatment group vs. 45.9 %, 48.6 % and 54.1%, respectively in Sulfasalazine group, P 〈 0.05）. CONCLUSION： Compound- dracorhodin coloclysis is superior to Sulfasalazine （SASP） coloclysis in that it has good efficacy yet with mild side - effects for patients with active ulcerative colitis.