美罗培南的药品不良反应文献分析

Analysis of Meropenem-induced Adverse Drug Reactions

目的:根据临床应用美罗培南引起药品不良反应(ADR)的文献,考查美罗培南的安全性。方法:通过中国生物医学文献数据库、万方数据库、中文科技期刊数据库(维普)收集1998～2008年临床资料,进行汇总、分析。结果:临床应用美罗沙星的1 675例病人共发生ADR163例(9.73%),涉及消化系统、皮肤系统、神经系统、血液系统、泌尿系统等9个系统。因ADR被迫停药3例。结论:临床应用中,应特别注意美罗培南消化系统和神经系统方面的ADR,密切关注血液系统实验室检查,监测肝、肾功能。

OBJECTIVE： To evaluate the safety of meropenem based on the literature about its adverse drug reactions （ADRs）. METHODS： The clinical data of ADRs of meropenem from 1998 to 2008 was retrieved from the databases of Biomedical Literature on disc, Wanfang Data and VIP Information and analyzed statistically. RESULTS： Of the total 1 675 meropenem-treated patients, 163 （9.73%） presented ADRs involving nine systems including digestive system, nervous system and cardiovascular system etc. Meropenem was withdrawn in 3 cases on account of ADRs. CONCLUSION： In clinical application of meropenem, special attention should be paid to its ADRs appeared in digestive system and nervous system, meanwhile, the hepatic and renal functions should be monitored by paying close attention to the laboratory test of hematological system.