多项生化检测指标对诊断早期糖尿病肾病的价值

Diagnostic value of multiple items determination in the diagnosis of early diabetic nephropathy

目的探讨糖尿病患者尿清蛋白/尿肌酐(UALB/UCr)、α1微球蛋白(α1-MG)、视黄醇结合蛋白(RBP)和血胱抑素C(CysC)、C反应蛋白(CRP)的变化对早期糖尿病肾病的诊断价值。方法对60例早期肾损伤的糖尿病患者和40例健康人的标本采用免疫散射比浊法检测尿α1-MG的水平,使用免疫透射比浊法检测尿UALB/UCr和血CysC、RBP、CRP的含量。结果糖尿病患者UALB/UCr、α1-MG、RBP、CysC、CRP显著高于健康人(P<0.01)。结论联合检测UALB/UCr、α1-MG、RBP、CysC、CRP对糖尿病肾病的早期诊断和评估有重要的临床价值。

Objective To investigate the diagnostic value of multiple items of urine albumin / urine creatinine（UAlb/UCr）,αlmieroglob- ulin （α1-MG） ,retinol binding protein （RBP） and serum Cystatin C（ Cys C ）,C-reactive protein （CRP） determination in the diagnosis of early diabetic nephropathy. Methods Immunity scatting turbidimetry was applied to measure the urine levels of albumin （Alb）,ereatinine （Cr） and α1microglobulin （α1-MG）, and immunity tnrbidimetry was applied measure the serum Cys C ,RBPand CRP levels in 60 patients with diabetes mellitus and 40 cases of healthy controls. Resealts The levels of UALB/UCr,α1-MG,RBP and serum,Cys C ,CRP in patients with diabetes mellitus were significantly higher than those of healthy controls （P〈0.01）. Conclusion Determination of urinary and serum proteins （including UAlb/UCr, α1-MG,RBP and serum Cys C,CRP） is helpful for the diagnosis and assessment of early diabetic nephropathy.