影响卵巢癌发生的相关因素研究

Case-control study on the risk factor of ovarian cancer

目的探讨影响卵巢癌发生的相关因素，为预防卵巢癌发生提供依据。方法采用病例对照研究方法，选择2007年7月至2009年2月辽宁省肿瘤医院收治卵巢癌患者243例为研究组，门诊确诊非恶性肿瘤（同时排除卵巢疾病）270例为对照组。采用调查表，对两组妇女进行调查，调查其一般情况、既往史、婚姻月经生育史、家族史及个人史等。采用单因素和多因素非条件logistic回归分析，对有统计学意义因素计算其卵巢癌发生绝对危险度（比值比，OR）及其95％可信区间（95％CI）。结果单因素非条件logistic分析显示痛经、初潮年龄、月经期、妊娠次数、自然流产、人工流产为有统计学意义因素。多因素非条件Logistic分析显示自然流产、人工流产、月经期为有统计学意义因素，OR及其95％C1分别为0．252（0．100～0．636）、4．199（2．710～6．504）、3．525（2．252～5．519）。结论足月妊娠、减少人工流产可能预防卵巢癌的发生。

Objective To estimate the risk factors and protective factors of ovarian cancer,and to provide proof for preventing against ovarian cancer. Methods The cases were selected from Liaoning Tumor Hospital between 2007 July to 2009 February. The number of patients who had been diagnosed as ovarian cancer was 243. The control came from the same hospital, who had been diagnosed as non-malignant tumor,the number of which was 270. Investigate the case histories of the case and the control with the investigated questionnaires. The main factors we wanted to investigate were the general state of health, the history of past illness, the marriage menstruation and childbearing history, family medical history, personal history etc. Compare the distribution of age, nation, occupation, engagement between the two groups, and observe whether they were significant. Have a single factor non-condition logistic regression analysis and a multiple factor non-condition logistic regression analysis of the data we had obtained. Results The single factor analysis indicates that algomenorrhea, menarche age, menstruation, the number of total pregnancy and the number of spontaneous abortion, the number of induced abortion were relevant to ovarian cancer. With the multiplicity, the factors enter the principal effect are.. the number of spontaneous abortion, the number of induced abortion and menstruation. The OR value were 0. 204（0. 081-0. 513） ,2. 755（1. 673 4. 538） ,3. 235（2. 054-5. 095） ,respectively. Conclusion Term pregnancy and reduced abortion may prevent the occurrence of ovarian cancer.