肾癌中MMP9、MMP11与细胞增殖活性和血管生成的关系

The relationship among MMP9,MMP11 and cell proliferation,angiogenesis in renal carcinoma

目的观察基质金属蛋白酶9(MMP9)和基质金属蛋白酶11(MMP11)在肾细胞癌组织中的表达及其与细胞增殖活性和血管生成的关系。方法应用免疫组织化学染色方法检测32例肾细胞癌组织中MMP9、MMP11、第八因子相关抗原(FⅧRAg)、α-平滑肌肌动蛋白(α-SMA)和增殖细胞核抗原(PCNA)的表达。结果MMP9和MMP11在瘤栓中呈强阳性表达,MMP9与MMP11均与FⅧ、α-SMA及PCNA表达密切相关。结论MMP9与MMP11在肾细胞癌增殖活性和血管生成方面均有重要作用。

Objective Study on the expression of MMP9 and MMp11 and the relationship among MMP9, MMP11 and cell proliferation, angiogenesis in renal carcinoma. Methods MMP9, MMP11, FⅧ Rag, α-SMA and PCNA were detecting by using immtmohistochemistry stain. Results MMP9 and MMP11 express in tumor embolus. There are correlation among MMP9, MMP11 and FⅧ Rag, α-SMA,PCNA.Condusion MMP9 and MMPll play important role in cell proliferation,angiogenesis in renal carcinoma.