同步换血疗法治疗新生儿败血症的疗效观察

The observing the curative effect of synchronized exchange transfusion on neonatal septicemia

目的探讨同步换血疗法对新生儿败血症的疗效。方法新生儿败血症患儿55例，随机分为同步换血治疗组25例，非换血治疗组30例。比较同步换血组与非换血组之间的病死率和住院时间，脏器功能受损的程度与病死率间的关系；比较同步换血治疗组患儿治疗前后血气值及肝、肾、生化等指标的变化。结果同步换血治疗组病死率及住院天数均明显低于非换血组垆〈0．05）。同步换血后酸中毒得到纠正，PaO2升高，PaCO2下降，同步换血后胆红素明显下降，尿素氮、肌酐明显下降（P〈0．05）而同步换血前后电解质，血糖变化不明显（P〉0．05）。结论同步换血疗法对新生儿败血症有较好的疗效。

Objective To explore curative effect of synchronized exchange transfusion on neonatal septicemia. Method Fifty-five cases of septic neonates were randomly divided into two groups, 25 cases for exchange transfusion group and 30 cases for non-exchange transfushion group. The mortalities, length of hospital stay, the relationship between injured degree of organ and mortalities were compared between two groups. Arterial blood gas, hepatic and renal faction were compared before and after transfusion in exchange transfusion group. Result The mortality and length of hospital stay were less in exchange transfusion group than that in non-exchange transfusion group （ P〈 0. 05 ） .Exchange transfusion improved acidosis and respiratory faction that showed PaO2 was increased and PaCO2was decreased. In addition, bilirubin, urea nitrogen and creatinine in serum were significantly decreased in exchange transfusion group compared to that of before transfusion （ P 〈 0.05 ） .The blood electrolyte and glucose did not change significantly （ P 〉 0.05 ） .Conclusion The synchronized exchange transfusion as a simple blood purification method was effective on neonate septicemia.