邯郸市乙肝病毒宫内感染现状的研究

Investigation on intrauterine infection status of hepatitis B virus in Handan city

目的:了解邯郸市孕妇乙肝病毒感染状况,HBsAg阳性孕妇孕期母婴阻断情况及其新生儿HBV宫内感染率。方法:对5343例孕妇进行HBsAg的检测,调查HBsAg阳性孕妇孕期阻断措施的实施情况,并对其新生儿进行静脉血HBsAg检测。结果:5343例孕妇中检出HBsAg阳性孕妇322例,感染率为6.03%,其中196例曾于妊娠最后3个月注射乙型肝炎免疫球蛋白(HBIG),但应用HBIG的孕妇其新生儿宫内感染率与未应用者比较无统计学差异(P>0.05)。结论:邯郸市孕妇HBsAg携带率正在不断下降,孕期应用HBIG的HBsAg阳性孕妇比例逐年增多,然而孕期应用HBIG对控制HBV宫内感染未见成效。

Objective： To study the hepatitis B virus （HBV） status in pregnant women of Handan city, interruption of maternal - infantile transmission and intrauterine infection rate of neonates. Methods： 5 343 pregnant women and their neonates were detected for HbsAg, the effect of blocking therapy in pregnant women with positive HbsAg result was investigated. Results ： 322 pregnant women were found with positive HbsAg, the infective rate was 6.03% , including 196 pregnant women injected by hepatitis B immunoglobulin （HBIG） three month before delivery. There was no significant difference in intrauterine infection rate between neonates whose mothers were injected and werenl （ P 〉 O. 05 ） . Conclusion： HBV infection rate of pregnant women in Handan city is decreasing, protective injection rate of HBIG is increasing, but injecting HBIG is ineffective to interruption of maternal- infantile transmission.