摘要
对近年来报道的各种高效液相色谱蛋白质手性固定相的研究进行了综述.主要介绍了蛋白质手性固定相的制备、分类、组成、性质、拆分机理及其应用,讨论了各类蛋白质手性固定相的优缺点,指出了目前存在的问题和今后的研究方向.
The enantioseparations of Various compounds using proteins as the chiral selectors in high-performance liquid chromatography (HPLC) were considered. The recent development in the classification, the preparation,the properties, the chiral recognition mechanism and the applications of chiral stationary phases used in high performance liquid chromatography were introduced. The advantages and disadvantages of different chiral stationary phases were also discussed. The problems at present, the research direction and focus for the future have been put forward.
出处
《河北师范大学学报(自然科学版)》
CAS
北大核心
2009年第3期362-367,共6页
Journal of Hebei Normal University:Natural Science
基金
河北省自然科学基金(E2006000167)
河北省教育厅科学研究项目(2006438)
关键词
高效液相色谱
蛋白质固定相
手性拆分
HPLC
protein-based chiral stationary phase
chiral resolution